14/06/2019
The Human Resources Strategy for Researchers

PhD in Bio-inspired, bioengineered and biomimetic T-cell-conjugated polymer vesicles: a biohybrid co

This job offer has expired


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    ChemistryPhysical chemistry
    PhysicsBiophysics
    PhysicsChemical physics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    05/07/2019 23:59 - Europe/Brussels
  • LOCATION
    France › PESSAC
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/09/2019

The Laboratory of Chemistry of Organic Polymers (LCPO) is a joint research unit affiliated to the CNRS, the University of Bordeaux and the Institut Polytechnique de Bordeaux (http://www.lcpo.fr). The LCPO is organized into 4 research teams with a total strength of nearly 150 people, including about 50 permanent staff.

With over 30 years of expertise in polymer chemistry, researches at LCPO aim at:
- developing innovative methodologies for precision synthesis of polymers, using in particular biomimetic and/or green chemistry pathways
- designing functional polymer materials by macromolecular engineering and self-assembly, in the fields of renewable materials, health and energy
- establishing strong links with the socio-economy world.

The work of the recruited agent will be carried out in team 3 of the LCPO and in collaboration with Immuno ConcEpT team (UMR5164, J. Dechanet-Merville) and ISM teams (UMR 5255, N. Mc Clenaghan).

Team 3 entitled "Self-assembly of Polymers and Life Sciences" is headed by Sébastien Lecommandoux. The team explores the design biomimetic and biofuntional nano and microparticles, especially polymersomes, with the following main focus:
- synthesis and self-assembly of block copolymers based on polypeptides, polysaccharides and proteins
- formulation of functional nanoparticles, including polymersomes, for the targeted delivery and controlled release of active ingredients (therapy and theranostic)
- design of artificial cells (protocells) as membrane models and biological factory.

The main objective of the multidisciplinary POLYCELL project concerns the design of “hybrid” systems that combine the most advanced and promising developments in nanomedicine and cell therapy. As such, custom-made functional polymersomes (polymer vesicles/microcapsules) will be covalently conjugated to lymphocytes (γδ T cells) in order to increase their accumulation in specific organs that are infected by the Cytomegalovirus virus (CMV). This virus is particularly resistant with a high morbidity in the context of organ transplantations. The Immuno ConcEpT team (UMR5164, J. Dechanet-Merville) has elucidated the role of γδ T cells with respect to CMV infection, and has the capability to isolate and culture them, not only in a murine model, which offers a proof-of-principle demonstrator in animals, but also in in a human model which allows validation of the concept with a realistic translational character. The LCPO (UMR5629, S. Lecommandoux) and ISM teams (UMR 5255, N. Mc Clenaghan) have developed polymersomes that, while highly stable and impermeable, are able to rupture and release their content in a controlled manner in terms of time, space and wavelength as a response to a photo-induced osmotic imbalance. Through POLYCELL, the proof of concept will be established on the CMV model, but importantly, this innovative medical approach can subsequently be further generalized and applied to a range of other diseases implying a major role of lymphocytes.
Unique training of early stage researchers will be assured, as well as efficient exchange and materials development, by the close proximity of the Bordeaux partners.

Required Research Experiences

  • RESEARCH FIELD
    ChemistryPhysical chemistry
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    PhysicsChemical physics
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    PhysicsBiophysics
  • YEARS OF RESEARCH EXPERIENCE
    None

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Physics: Master Degree or equivalent
  • REQUIRED LANGUAGES
    FRENCH: Basic
Work location(s)
1 position(s) available at
LABORATOIRE DE CHIMIE DES POLYMERES ORGANIQUES
France
PESSAC

EURAXESS offer ID: 417261
Posting organisation offer ID: 10139

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